Nanocrystal-Based Topical Gels for Improving Wound Healing Efficacy of Curcumin

Topical curcumin shows poor local availability because of its low aqueous solubility and inadequate tissue absorption. Curcumin nanocrystals were prepared by sonoprecipitation followed lyophilization to improve surface area solubility. The formulation was optimized the Design Experiment (DoE) approach. characterized for particle size, zeta potential, polydispersity index, scanning electron microscopy (SEM), powder x-ray diffraction (PXRD), practical yield in vitro drug release studies. nanocrystal-incorporated gel evaluated content, ex vivo permeation, skin irritation, wound healing activity. Time sonication amplitude influenced optimization nanocrystals, but effect stabilizer concentrations not significant beyond 0.5% w/w. SEM images revealed irregular plate-shaped particles with rough surfaces. PXRD patterns showed crystallinity compared unprocessed powder. An study demonstrated improvement percentage cumulative form curcumin, profile exhibited first-order kinetics. nanocrystal 93.86% content free irritation potential. Excision activity albino rats that significantly faster contraction than powder-incorporated gel.